Percutaneous
Absorption Assays
GLP and GMP-certified percutaneous absorption assessments for topical products with extensive hands-on expertise in comprehensive IVRT & IVPT studies.
Pioneering Topical Formulations
BrownBiology Laboratory is one of the few global Contract Research Organizations (CROs) offering both fully GLP- and GMP-certified percutaneous absorption assays specifically mapped out for topical products. We utilize the latest automated Hanson vertical diffusion Phoenix instruments to elevate classic Franz cells methodologies.
These precision assays are built directly for developers and manufacturers of topical products and cosmetics in need of dermal formulation characterizations, rigorous cosmetic safety screening, or biowaivers for topical generics via robust in vitro bioequivalence workflows.
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Core Assays & Applications
In Vitro Release Test (IVRT)
Drug released amounts and rates for transdermal semisolid topical products are masterfully measured by means of IVRT utilizing artificial membranes in distinct topical applications:
- Optimization and quantitative comparison of different formulations during developmental phases.
- Development and validation of methods to measure exact release rates for divergent topical formulations.
- Quality control benchmarking for the in vitro release profile of massive manufacturing batches.
In Vitro Permeation Test (IVPT)
Transdermal permeated bulk amounts, absolute flux rates, and microscopic layer distributions are carefully measured by means of IVPT applied over validated skin samples and matrices:
- Bioequivalence qualification of topical generics deployed as an EMA/FDA-approved biowaiver alternative to costly clinicals.
- Optimization/comparison of formulations dictating the optimal selection of suitable bio-excipients.
- Physical skin stripping and layering dynamics evaluating direct cosmetic product safety. Percutaneous absorption studies across skin or cornea matrices.
Why Us for Absorption Studies?
Global Trust
We are trusted by clients worldwide and seamlessly support projects spanning from initial formulation development to complex regulatory submissions.
Regulatory Excellence
In vitro method development executed in compliance with SUPAC-SS and FDA requirements (Guidance for Industry: SUPAC_SS: Nonsterile Semisolid Dosage Forms. FDA, 1997) as well as the Guideline on Quality and Equivalence of Topical Products (EMA, 2024).
Extensive Expertise
BrownBiology Laboratory hosts a highly specialized scientific team executing IVRT & IVPT projects since 2017, functioning in full compliance with the most rigorous international guidelines.
State-of-the-art Equipment
Equipped with the latest automated Hanson vertical diffusion Phoenix instruments to perform high-throughput Franz cell testing with absolute precision.
Securing Superior Permeation Protocols
Launch your upcoming topical generic or cosmetic product with confidence via our state-of-the-art methodology profiling.