Peptide & Oligonucleotide Services
Sophisticated synthesis support and analytical control for the next generation of TIDES therapeutics.
Precision at the Molecular Level
The distinct chemistry of peptides and oligonucleotides requires a specialized analytical approach. BrownBiology Laboratory offers a comprehensive suite of services for TIDES (Peptides and Oligonucleotides), covering everything from raw material qualification to finished product release.
Peptide Capabilities
- 鈥?Sequence verification by MS/MS.
- 鈥?Counter-ion and moisture content (Karl Fischer).
- 鈥?Amino acid quantification and UV-extinction.
- 鈥?Residual solvent analysis (USP <467>).
Oligonucleotide Suite
- 鈥?Purity by IP-RP-HPLC and Ion Exchange.
- 鈥?Molecular weight by ESI-MS and MALDI.
- 鈥?Thermal melting point (Tm) analysis.
- 鈥?Impurity profiling (N-1, N+1, depurination).
Expert Method Development
We specialize in developing and validating stability-indicating methods for complex modified peptides and siRNA/ASO molecules. Our expertise includes handling PEGylated compounds and lipid nanoparticle (LNP) encapsulated payloads.
21 CFR Part 11 Compliant DataPhase-Appropriate Validation
Support Your Chemistry
From discovery-stage characterization to clinical-batch release, our TIDES experts are here to support your CMC strategy.
Get a Technical Quote