Get to know our
Facilities
BrownBiology Laboratory is a US-based CRO comprising cutting-edge facilities with 14 laboratory departments, 240 highly trained experts, and 5,000 m虏 worth of laboratory space and top-of-the-line instruments.
Our Laboratories
Our GMP/GLP-certified bioanalytical and CMC services are carried out by specialized teams in our dedicated laboratories across the United States.
In addition to our main laboratories, we are equipped with adjacent facilities for weighting, sample preparation and processing; a combined 100m鲁 of SCADA-monitored sample storage chambers under all ICH climatic conditions including standard and IVb zones, back-up room, refrigerated conditions, -20潞C freezers and -80潞C ultra-freezers; a microbiology cleanroom for aseptic testing and sample preparation; a containment room for work under O.E.L. Category 4 with high-potency drugs such as hormones, antibiotics or cytotoxins; a radioactivity laboratory to work with Iodine-125; purified water and technical-gas plants; emergency power generators; a fireproof data center for communication and software servers, data storage and back-up systems; as well as offices, meeting rooms, cafeteria and general facilities.
Technology
Our Cutting-Edge Expertise
Our facilities are equipped with advanced instruments, innovative techniques, and a rigorous methodology to ensure precision, compliance, and efficiency in every analytical process.
Instruments
We are equipped with state-of-the-art instrumentation to ensure the highest accuracy and reliability in our analyses. Our laboratories feature advanced LC-MS/MS, HRMS, ICP-MS, qPCR, and ELISA platforms, as well as specialized systems for chromatography, spectrometry, electrophoresis, and immunoassays, among others. With cutting-edge automation and digital integration via LIMS, we guarantee precise, reproducible, and regulatory-compliant results for every project.
Techniques
We employ a broad range of analytical techniques to support pharmaceutical development, from early-stage research to commercial batch release. Our expertise includes mass spectrometry, ligand-binding assays, electrophoretic separations, and cell-based bioassays, among others. With a strong focus on regulatory compliance, we develop, validate, and apply industry-leading methods to ensure the integrity and quality of your drug development pipeline.
Methodology
Our methodology is designed to optimize efficiency and compliance across all phases of pharmaceutical analysis. We follow a structured approach, starting with feasibility assessments and method development, followed by rigorous validation and routine analysis under GLP/GMP conditions. Our team ensures that every project is executed with precision, using robust quality systems and advanced digital tools for data integrity and traceability.
Equipment
Our Platforms & Equipment
All our laboratories feature state-of-the-art instrumentation to ensure precise and reliable analysis for our clients.
Mass Spectrometry
- AB SCIEX LC-MS/MS API 3.200 (1), 4.000 (6), 5.500 Qtrap (2), 6.500 Plus (2) and 6.500 Plus QTRAP (1)
- Qtof Xevo G2-S with BiopharmaLynx and MaxEnt mass spectrometer
- ICP/MS Agilent 7.700 and 7.800 (2) and digestion system Milestone Ultrawave (2)
- LC-MS/MS Infinity with MS 6491 Agilent (2)
- GC-MS Agilent
- Orbitrap Exploris鈩?120 Mass Spectrometer
Liquid Chromatography
- HPLC Alliance Waters and Agilent 1100, 1200, 1260 (38 units) coupled to UV diode array, fluorescence, refraction index, electrochemical, amperometry, light scattering, CAD and mass detector QDa.
- UHPLC (8): Agilent 1290 and Waters Acquity
- Agilent Gas chromatography (6) coupled to head-space injection system, with FID/ECD detection
- Agilent atomic absorption spectrometer
- Mercury analyzer DMA-80 Milestone
- UV-visible spectrophotometer (diode array)
- FTIR Cary 630 Agilent
Immunology
- WIZARD gamma counter for RIA assays
- SpectraMax M3/M5 microplate ELISA reader (2)
- Biotek Epoch / Synergy microplate ELISA reader (2)
- MESO QuickPlex SQ 120 Meso Scale Discovery for ECLA
- Guava easyCyte flow cytometer for cell assays
- Pharmacia PhastSystem high speed electrophoresis
- Multhiphore II electrophoresis system GE (2)
- GS-900 calibrated densitometer for electrophoresis
- Agilent 2100 Bioanalyzer chip electrophoresis
- Solo VPE UV-visible spectrophotometer
- Agilent capillary electrophoresis with LIF detection
- Beckman PA800S Plus capillary electrophoresis (2)
- Protein Simple Image isoelectric focusing iCE3
- QuantStudio 7 Flex real time qPCR
- King Fisher Flex benchtop sample prep. instrument
- Cell laboratory fully equipped (2)
Special Lab Instruments
- Franz cells Crown Glass V-Series manual (1 instruments, 9 cells)
- Franz cells Phoenix RDS automatic (2 instruments, 12 cells each)
- Climatic chambers for ICH stability studies and photostability chamber
- Dissolution test (8), disintegrating test and friability test
- Particle size Malver Mastersizer 3000
- Cascade impactor for OINDP (Andersen and NGI)
- Viscosimeter, polarimeter, Karl Fischer (volumetric and coulometric), melting point, osmometer (2)
- Subvisible particles Pamas (2)
- TOC analyzer
- Microbiology laboratory fully equipped
- Isolator (for sterility testing)
- Zwick Roel universal testing machines (syringes and autoinjectors)
Other Available Instruments
- Maldi TOF 鈥?NMR systems
- SPR (Biacore T200)
- Circular Dicroism
- Protein sequencer (Edman degradation)