Biomarker
Analysis Services

GLP-certified & GCP-compliant analysis services for biomarkers across multiple therapeutic areas using MSD庐, Luminex庐, qPCR, and LC-MS/MS technologies.

MSD庐 MultiplexLuminex庐GLP/GCP Compliant

Expertise in Biomarker Determination

BrownBiology Laboratory is a GLP-certified and GCP-compliant multinational CRO inspected by the EMA and FDA. Our team of experts provides biomarker analysis, supporting you across all phases, from drug discovery to clinical sample analysis reaching multiple therapeutic areas.

Equipped with state-of-the-art technologies and techniques such as Meso Scale Discovery (MSD庐), Luminex庐, qPCR, and LC-MS/MS, we offer a comprehensive catalog of biomarkers. We are proficient in developing new methods from scratch, performing fit-to-purpose qualification or validation, and handling pharmacodynamic studies to determine drug efficacy and safety.

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Biomarker Analysis Laboratory

Main Service Capabilities

We adapt and customize the biomarker determination according to each Clinical or Preclinical study鈥檚 specific requirements.

  • Protein (cytokines, hormones, antibodies, growth factors, etc.) biomarker analysis (MSD庐, Luminex庐).
  • Genetic (RNA, mRNA, miRNA, etc.) biomarker analysis (qPCR, Hybridization ELISA, LC-MS/MS, MSD庐).
  • Small molecule biomarker analysis (LC-MS/MS).
  • Fit-to-purpose biomarker immunoassay qualification and validation.
  • Exploratory screenings of biomarkers for use as an endpoint in future clinical trials.
  • Development of methods from scratch and customized multiplexing panels.
  • Pharmacodynamic studies for drug efficacy and safety.
  • Broad spectrum of species (human, mouse, NHP, rat, canine, chicken, pig, and others).
  • Determination in several matrices (plasma, serum, CSF, cell culture supernatant, cell homogenates, urine, saliva, and others).

MSD庐 (ECLA) for Protein Multiplex Analysis

Equipped with MESO Quickplex SQ 120 Meso Scale Discovery, offering multiplex immunoassays based on electrochemiluminescence (ECLA).

  • 鈻?/span>Single or multiplex assays with up to 10 analytes per well.
  • 鈻?/span>Higher sensitivity than ELISA with broad dynamic range (4-5 logs).
  • 鈻?/span>Assay kits targeting specific criteria: V-PLEX, U-PLEX, S-PLEX, R-PLEX, and T-PLEX platforms.

Luminex庐 Multiplexing Technology

Luminex xMAP庐 technology is a bead-based immunoassay that provides simultaneous detection of several analytes in a single well.

  • 鈻?/span>Up to 80 analytes in a single well with 5.5 logs of enhanced dynamic range.
  • 鈻?/span>Low volume of sample required (less than 25 渭L).
  • 鈻?/span>Access to +600 protein targets from different species.

Covered Therapeutic Areas

Inflammatory Biomarkers

Inflammatory panels (IFN-纬, TNF-伪, IL-1伪, IL-1尾, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, CRP, etc.) and Cytokine/Chemokine panels (MCP-1, Eotaxin, IP-10, MIP-1伪, GM-CSF, IL-17A, etc.)

Vascular & Angiogenesis

Vascular and Angiogenesis panels (FGF, VEGFR, VEGF-A, VEGF-C, VEGF-D, ICAM-1, VCAM-1, Ang-1, Ang-2 to name a few)

Systemic Disease

Kidney Injury panels (Albumin, Calbindin, HAVCR1/KIM-1, VEGF-A) and Metabolic panels (Insulin, Leptin, GIP, GLP-1, C-Peptide, Adiponectin, Clusterin)

Cardiology Biomarkers

Cardiovascular and Cardiac Injury panels (BNP, NT proBNP, Myoglobin, CK, CK-MB, Troponin I, Troponin T, HGF, FABP3, Tissue Factor)

Oncology Biomarkers

Oncology panels (Galectin, BTLA, AFP, CA-9, CA125, CD80/B7-1, CEA, CTLA-4, PD-L1, hyaluronidase and more)

Neurology Biomarkers

Neurology and Neuroinflammation panels (A尾38, A尾40, A尾42, APP, Tau, pTau, BDNF, 伪-Synuclein, NfL, NfH, S100B and more)

Why Choose BrownBiology?

Regulatory Excellence

FDA and EMA inspected, GLP-certified, and committed to GCP compliance ensuring the highest quality standards.

Global Trust

We are a trusted and reliable partner to pharmaceutical innovators worldwide, advancing personalized medicine.

Extensive Expertise

Extensive experience supporting clients across all phases (discovery to clinical) delivering tight timelines and sustainable prices.

State-of-the-Art Equivalency

Equipped with cutting-edge platforms: MESO Quickplex SQ120 Meso Scale Discovery, and Luminex xMAP multiplexing technology.

Discuss Your Biomarker Strategy

Let our experts design the optimal multiplexing or biomarker analysis strategy for your clinical endpoints.

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